Journal
CURRENT COMPUTER-AIDED DRUG DESIGN
Volume 7, Issue 3, Pages 214-227Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157340911796504323
Keywords
AMP-activated protein kinase; activator; structure-based drug design; ligand-based drug design; fragment-based drug design; structural analysis
Funding
- National Natural Science Foundation of China [20902068]
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AMP-activated protein kinase (AMPK) is an important therapeutic target for the potential treatment of metabolic disorders, cardiovascular disease and cancer. Recently, various classes of compounds that activate AMPK by direct or indirect interactions have been reported. The importance of computer-aided drug design approaches in the search for potent activators of AMPK is now established, including structure-based design, ligand-based design, fragment-based design, as well as structural analysis. This review article highlights the computer-aided drug design approaches utilized to discover of activators targeting AMPK. The principles, advantages or limitation of the different methods are also being discussed together with examples of applications taken from the literatures.
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