Journal
CURRENT CANCER DRUG TARGETS
Volume 13, Issue 9, Pages 957-962Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/15680096113136660101
Keywords
Cancer; miRNA; natural compound; notch; oncogene; tumor suppressor gene
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Funding
- NSFC [81172087]
- Anhui Provincial Natural Science Foundation [1208085MH170]
- Natural Science Research key Project of Education Office of Anhui Province [KJ2012A196]
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Notch signaling pathway has been reported to play critical roles in the development and progression of human cancers because Notch signaling pathway is critically involved in many cellular processes including cell proliferation, survival, apoptosis, migration, invasion, angiogenesis, and metastasis. Emerging evidence suggests that Notch regulates EMT (Epithelial-to-Mesenchymal Transition), leading to tumor invasion and metastasis. Thus, this mini-review is focused on discussing the novel role of Notch signaling pathway in the regulation of EMT. Moreover, we summarized that Notch signaling pathway could be down-regulated by its inhibitors or natural compounds, resulting in the reversal of EMT to MET (Mesenchymal-to-Epithelial Transition), which could be a promising strategy for achieving better treatment outcome in patients diagnosed with cancer.
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