Journal
CURRENT BIOLOGY
Volume 24, Issue 10, Pages R424-R434Publisher
CELL PRESS
DOI: 10.1016/j.cub.2014.03.023
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Funding
- NIGMS NIH HHS [R01 GM036278, T32 GM007810] Funding Source: Medline
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Microorganisms live in fluctuating environments, requiring stress response pathways to resist environmental insults and stress. These pathways dynamically monitor cellular status, and mediate adaptive changes by remodeling the proteome, largely accomplished by remodeling transcriptional networks and protein degradation. The complementarity of fast, specific proteolytic degradation and slower, broad transcriptomic changes gives cells the mechanistic repertoire to dynamically adjust cellular processes and optimize response behavior. Together, this enables cells to minimize the 'cost' of the response while maximizing the ability to survive environmental stress. Here we highlight recent progress in our understanding of transcriptional networks and proteolysis that illustrates the design principles used by bacteria to generate the complex behaviors required to resist stress.
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