Journal
CURRENT BIOLOGY
Volume 24, Issue 11, Pages 1241-1247Publisher
CELL PRESS
DOI: 10.1016/j.cub.2014.04.014
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Funding
- BBSRC (UK)
- Biotechnology and Biological Sciences Research Council [1200479, BB/I017836/1] Funding Source: researchfish
- BBSRC [BB/I017836/1] Funding Source: UKRI
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A key task for the visual system is to combine spatially overlapping representations of the environment, viewed by either eye, into a coherent image. In cats and primates, this is accomplished in the cortex [1], with retinal outputs maintained as separate monocular maps en route through the lateral geniculate nucleus (LGN). While this arrangement is also believed to apply to rodents [2, 3], this has not been functionally confirmed. Accordingly, here we used multielectrode recordings to survey eye-specific visual responses across the mouse LGN. Surprisingly, while we find that regions of space visible to both eyes do indeed form part of a monocular representation of the contralateral visual field, we find no evidence for a corresponding ipsilateral representation. Instead, we find many cells that can be driven via either eye. These inputs combine to enhance the detection of weak stimuli, forming a binocular representation of frontal visual space. This extensive thalamic integration marks a fundamental distinction in mechanisms of binocular processing between mice and other mammals.
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