Journal
CURRENT BIOLOGY
Volume 22, Issue 1, Pages R29-R34Publisher
CELL PRESS
DOI: 10.1016/j.cub.2011.11.034
Keywords
-
Categories
Funding
- Legacy Heritage Fund
- Israeli Science Foundation ISF
- German Israeli Foundation GIF
- Louis Brause Philanthropic Fund
- Wellcome Trust
- MRC
- Wellcome Trust/MRC
- NIHR Biomendical Research Centre at Addenbrooke's Hospital
- MRC [MC_G1000734, G0600194] Funding Source: UKRI
- Medical Research Council [G0600194, MC_G1000734] Funding Source: researchfish
Ask authors/readers for more resources
Autophagy is a unique membrane trafficking process whereby newly formed membranes, termed phagophores, engulf parts of the cytoplasm leading to the production of double-membraned autophagosomes that get delivered to lysosomes for degradation. This catabolic pathway has been linked to numerous physiological and pathological conditions, such as development, programmed cell death, cancer, pathogen infection, neurodegenerative disorders, and myopathies. In this review, we will focus on recent studies in yeast and mammalian systems that have provided insights into two critical areas of autophagosome biogenesis - the source of the autophagosomal membranes, and the mechanisms regulating the fusion of the edges of the double-membraned phagophores to form autophagosomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available