Journal
CURRENT BIOLOGY
Volume 22, Issue 16, Pages R648-R657Publisher
CELL PRESS
DOI: 10.1016/j.cub.2012.07.025
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Funding
- National Institutes of Health (NIH) [GM067837, GM056006]
- Department of Energy [DE-SC0006621]
- National Institutes of Health under Ruth L. Kirschstein National Research Service Award [F32GM090378]
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Endogenous circadian rhythms regulate many aspects of an organism's behavior, physiology and development. These daily oscillations synchronize with the environment to generate robust rhythms, resulting in enhanced fitness and growth vigor in plants. Collective studies over the years have focused on understanding the transcription-based oscillator in Arabidopsis. Recent advances combining mechanistic data with genome-wide approaches have contributed significantly to a more comprehensive understanding of the molecular interactions within the oscillator, and with clock-controlled pathways. This review focuses on the regulatory mechanisms within the oscillator, highlighting key connections between new and existing components, and direct mechanistic links to downstream pathways that control overt rhythms in the whole plant.
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