Journal
CURRENT BIOLOGY
Volume 22, Issue 18, Pages 1699-1704Publisher
CELL PRESS
DOI: 10.1016/j.cub.2012.07.005
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Funding
- Federation of European Biochemical Societies
- University of Oxford Glasstone Research Fellowship
- Biotechnology and Biological Sciences Research Council Career Development Fellowship [BB/G023905/1, BB/F012934/1]
- European Molecular Biology Organization Young Investigator Programme
- Royal Society Wolfson Merit Award
- Max Planck Society core grant
- European Commission (FP7-ITN SIREN) [214788-2]
- Human Frontier Science Program [RGP0047/2010]
- BBSRC [BB/G023905/1, BB/F012934/1] Funding Source: UKRI
- EPSRC [EP/I017909/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F012934/1, BB/G023905/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I017909/1] Funding Source: researchfish
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The hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate [1-6]. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that the HD-ZIPIII transcription factor PHABULOSA (PHB) directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell differentiation and regulating root length. We further demonstrate that CK feeds back to repress both PHB and microRNA165, a negative regulator of PHB. These interactions comprise an incoherent regulatory loop in which CK represses both its activator and a repressor of its activator. We propose that this regulatory circuit determines the balance of cell division and differentiation during root development and may provide robustness against CK fluctuations.
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