Journal
CURRENT BIOLOGY
Volume 21, Issue 9, Pages R346-R355Publisher
CELL PRESS
DOI: 10.1016/j.cub.2011.03.015
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Funding
- NIH [GM060396-ES010337]
- NSF [MCB0918220]
- Division of Chemical, Geo and Biosciences at the Office of Energy Biosciences of the Department of Energy [DE-FG02-03ER15449]
- SNF fellowship
- Alexander von Humboldt-Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0918220] Funding Source: National Science Foundation
- U.S. Department of Energy (DOE) [DE-FG02-03ER15449] Funding Source: U.S. Department of Energy (DOE)
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The plant hormone abscisic acid (ABA) mediates seed dormancy, controls seedling development and triggers tolerance to abiotic stresses, including drought. Core ABA signaling components consist of a recently identified group of ABA receptor proteins of the PYRABACTIN RESISTANCE (PYR)/REGULATORY COMPONENT OF ABA RECEPTOR (RCAR) family that act as negative regulators of members of the PROTEIN PHOSPHATASE 2C (PP2C) family. Inhibition of PP2C activity enables activation of SNF1-RELATED KINASE 2 (SnRK2) protein kinases, which target downstream components, including transcription factors, ion channels and NADPH oxidases. These and other components form a complex ABA signaling network. Here, an in depth analysis of the evolution of components in this ABA signaling network shows that (i) PYR/RCAR ABA receptor and ABF-type transcription factor families arose during land colonization of plants and are not found in algae and other species, (ii) ABA biosynthesis enzymes have evolved to plant- and fungal-specific forms, leading to different ABA synthesis pathways, (iii) existing stress signaling components, including PP2C phosphatases and SnRK kinases, were adapted for novel roles in this plant-specific network to respond to water limitation. In addition, evolutionarily conserved secondary structures in the PYR/RCAR ABA receptor family are visualized.
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