4.8 Editorial Material

Sex Determination: Switch and Suppress

Journal

CURRENT BIOLOGY
Volume 21, Issue 17, Pages R656-R659

Publisher

CELL PRESS
DOI: 10.1016/j.cub.2011.07.026

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The transcription factor Dmrt1 regulates male sexual development from flies and worms to humans. A newly discovered function is to suppress female differentiation in the testes. Thus, the gonadal fate decision is not final but has to be actively maintained throughout life.

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