Journal
JOURNAL OF NEUROINFLAMMATION
Volume 12, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12974-015-0384-7
Keywords
Anterior thalamic nucleus; Thalamus; Seizures; Deep brain stimulation; Epilepsy; Apoptosis; Neuroprotection; Caspase
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Funding
- FAPESP [2011/50680-2, 2012/50950-2, 2012/10764-5]
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Background: Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis. Objective: The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE. Methods: Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment. Results: In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor alpha (TNF alpha). Conclusions: DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.
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