Journal
CURRENT BIOLOGY
Volume 19, Issue 9, Pages R381-R386Publisher
CELL PRESS
DOI: 10.1016/j.cub.2009.03.057
Keywords
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Categories
Funding
- NSF
- [DC008743]
- [DC005987]
- [DC008973]
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The lateral line organ is a mechanosensory organ of fish and amphibians that detects changes in water flow. The lateral line organ of zebrafish has been used as a model for cell polarity and collective cell migration as well as hair cell loss and regeneration. A combination of genetic tools and live imaging has allowed dissection of signaling pathways that regulate these processes. Here, we summarize recent findings on the roles of the FGF, Wnt/beta-catenin, and Notch pathways in the initial formation of the posterior lateral line primordium, as well as during organ patterning, migration, cell fate specification and hair cell regeneration.
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