Journal
CURRENT BIOLOGY
Volume 19, Issue 20, Pages R950-R952Publisher
CELL PRESS
DOI: 10.1016/j.cub.2009.08.051
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Funding
- NHLBI NIH HHS [R01 HL055426] Funding Source: Medline
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Receptor-induced Ca(2+) oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca(2+) levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Call entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.
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