Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 286, Issue -, Pages 33-41Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.07.003
Keywords
Autism; IL-17; Asthma; Food allergies
Categories
Funding
- National Institute of Environmental Health Sciences (NIEHS) pre-doctoral training program in Environmental Health Sciences [T32-ES007058-33]
- NIEHS Center for Children's Environmental Health [2P01ES011269-11]
- Environmental Protection Agency (EPA) [83543201]
- NIEHS [R01ES015359]
- NICHD [IDDRC 054, U54HD079125]
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Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls. (C) 2015 Elsevier B.V. All rights reserved.
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