Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 289, Issue -, Pages 143-151Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.11.003
Keywords
Controlled cortical impact; Epileptogenesis; LPS preconditioning; PTZ kindling
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Funding
- Pasteur Institute of Iran [634]
- Iran University of Medical Sciences. [15734]
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10-20% of symptomatic epilepsies are post-traumatic. We examined effect of LPS preconditioning on epileptogenesis after controlled cortical impact (CCI). LPS (0.01, 0.1 and 0.5 mg/kg) was injected i.p. to rats 5 days before induction of CCI to parieto-temporal cortex. Kindling started 24 h after CCI by i.p. injection of 30 mg/kg of pentylenetetrazole every other day until manifestation of 3 consecutive generalized seizures. CCI injury accelerated the rate of kindled seizures acquisition. LPS (0.1 and 0.5 mg/kg) prevented the acceleration of kindling. LPS preconditioning significantly decreased IL-1 beta and TNF-alpha over-expression and the number of damaged neurons in the hippocampus of traumatic rats. (C) 2015 Elsevier B.V. All rights reserved.
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