Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naive HIV-infected Thais

HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naive, MN-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2(+) non-classical monocytes were associated with worse neuropsychological test performance (r = 0.43, p = 0.024). CCR2(+) non-classical monocyte count inversely correlated with CSF neopterin (r = 0.43, p = 0.035) and plasma TNF-alpha. levels (r = 0.40, p = 0.041). These data benchmark CCR2+non-classical monocytes as an independent index of cognitive impairment. (C) 2015 Elsevier B.V. All rights reserved.