Journal
CURRENT ATHEROSCLEROSIS REPORTS
Volume 15, Issue 10, Pages -Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11883-013-0359-z
Keywords
Atherosclerosis; Plaque rupture; Molecular imaging; Myocardial infarction; Thrombosis
Categories
Funding
- NIH [R01 HL108229]
- MGH SPARK Award
- American Heart Association [13GRNT1760040]
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Atherosclerosis imaging strategies can delineate characteristics of plaques at risk of rupture and thrombosis. Structural plaque imaging identifies high-risk plaque features, including lipid pools, thin fibrous caps, and intraplaque hemorrhage. New molecular imaging techniques complement structural imaging approaches by illuminating important features of plaque biology, with a prominent focus on detecting inflammation as a high-risk phenotype. As we unravel the molecular and structural characteristics underlying thrombosis-prone plaques, there is significant promise for eventual early identification and prediction of atherosclerotic plaque complications before they occur. Here we focus on recent imaging insights into high-risk arterial plaques, the etiologic agent of acute myocardial infarction, stroke, and sudden cardiac death.
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