Journal
CURRENT ATHEROSCLEROSIS REPORTS
Volume 14, Issue 3, Pages 277-283Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11883-012-0242-3
Keywords
Myeloperoxidase; Acute coronary syndrome; Cardiovascular disease; Atherogenesis
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Myeloperoxidase (MPO), a member of the heme peroxidase superfamily, is a leukocyte-derived enzyme that generates reactive intermediates, leading to oxidative damage of host lipids and proteins. It has been shown that MPO is present within atherosclerotic plaque in human arteries and contributes to atherogenesis by catalyzing oxidative reactions in the vascular wall. This review provides an overview of the analytical and pathophysiologic characteristics of MPO and summarizes the possible clinical applicability of MPO as a marker for diagnosis of acute coronary syndrome and a marker for prediction of cardiovascular disease.
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