Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 280, Issue -, Pages 21-28Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.02.001
Keywords
Vitamin D; Relapsing-remitting multiple sclerosis; Interferon-beta treatment
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To explore if vitamin D modulates interferon-beta 1a treatment effects in relapsing-remitting multiple sclerosis, we examined relationships between serum vitamin D and magnetic resonance imaging (MRI) activity and ten systemic inflammation markers in 88 patients, before and during treatment. Odds ratios for all MRI parameters were negatively associated with vitamin D levels before therapy, but converged to equally low values irrespective of vitamin D status during treatment. During therapy, similar alterations of MRI activity and inflammation markers were found across patients categorized by mean vitamin D values. This suggests that vitamin D status has no major influence on interferon-beta 1a treatment effects. (C) 2015 Elsevier B.V. All rights reserved.
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