4.4 Article

Proteomics in Atherosclerosis

Journal

CURRENT ATHEROSCLEROSIS REPORTS
Volume 10, Issue 3, Pages 209-215

Publisher

CURRENT MEDICINE GROUP
DOI: 10.1007/s11883-008-0033-z

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Funding

  1. Spanish Ministerio de Ciencia y Tecnologia (SAF) [SAF2007/63648, S2006/GEN-0247]
  2. Ministerio de Sanidad y Consurno
  3. Instituto de Salud Carlos III
  4. Red RECAVA [RD06/0014/0035]
  5. Fundacion Ramon Areces

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Atherothrombosis is the underlying cause of several clinical manifestations, such as acute coronary syndromes, cerebrovascular disease, and peripheral artery disease, which together are the leading cause of death in the Western world. Proteins from vascular cells or atherosclerotic plaques that are present in plasma are modified along the different steps of atherosclerotic development and constitute target candidates for vascular research, particularly in the search for novel biological markers of cardiovascular risk. In this review, we summarize proteomic techniques and the most recent results obtained by application of these high-throughput strategies to cardiovascular samples.

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