Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 285, Issue -, Pages 156-160Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.06.012
Keywords
Multiple sclerosis; Epstein-Barr virus; Intrathecal immunoglobulin G; Oligoclonal bands; Epstein-Barr nuclear antigen-1; Antibodies
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Funding
- German Ministry of Education and Research (BMBF/KKNMS, Competence Network Multiple Sclerosis) [01GI1312]
- Charite Research Fund
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Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection. A characteristic feature of MS is an intrathecal synthesis of immunoglobulin (Ig)G. In 90 patients with clinically isolated syndromes/early relapsing-remitting MS, serum antibodies to Epstein-Barr nuclear antigen-1, but not to EBV viral capsid antigen, rubella, or varicella zoster virus, were higher (p = 0.03) in those with than those without a calculated intrathecal IgG synthesis >0% and correlated with the percentage (r = 0.27, p = 0.009) and concentration (r = 0.27, p = 0.012) of intrathecally produced IgG. These findings suggest a link between EBV infection and the events leading to intrathecal IgG synthesis in patients with MS. (C) 2015 Elsevier B.V. All rights reserved.
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