Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 278, Issue -, Pages 1-10Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.11.022
Keywords
Animal model; Thiopalmitoylated PO peptide; Chronic EAN; CIDP; Electrophysiology; Sciatic nerve immunohistochemistry; Immunology
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Funding
- AFMTelethon [MNM2 2010, MNM1 2013]
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Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17(+) cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies. (C) 2014 Elsevier B.V. All rights reserved.
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