Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 283, Issue -, Pages 43-49Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.04.012
Keywords
Neuroinflammation; Dynamic bayesian network; Chronic constriction injury; Neuropathic pain; IL-18
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Funding
- Pittsburgh Tissue Engineering Initiative
- NIH grant [P50-GM-53789]
- Duquesne University
- Duquesne University Chronic Pain Research Consortium
- Provost's Interdisciplinary Research Consortia Grant, Duquesne University
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Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy. (C) 2015 Elsevier B.V. All rights reserved.
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