Journal
CURRENT ALZHEIMER RESEARCH
Volume 8, Issue 4, Pages 336-340Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156720511795745302
Keywords
Resilience; cognitive reserve; dementia; cognitive decline
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Funding
- NIA NIH HHS [K08 AG033101, K08 AG033101-01, P30 AG010161-14, R01 AG017917, R01 AG015819, P30 AG010161, P30 AG010124, R01 AG039478, P30 AG010124-20] Funding Source: Medline
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It is increasingly recognized that the correlation between neuropathological lesions and cognition is modest and accounts for about a quarter of the variance of cognition among older adults. Some individuals maintain normal cognitive functioning amidst significant brain pathology, while others suffer varying degrees of cognitive and neurological deterioration that render them dependent and frail. We present data from the Religious Orders Study and the Memory and Aging Project pertaining to pathology and cognition, and propose a paradigm shift in consideration of the neurobiology of healthy aging and dementia. Factors that modify or mediate the association between neuropathology and cognition are also discussed. It is hypothesized that the concept of resilient aging can serve as a useful entity in understanding mechanisms that underlie healthy aging amidst disease-related pathology.
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