Journal
CURRENT ALZHEIMER RESEARCH
Volume 6, Issue 3, Pages 196-204Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156720509788486608
Keywords
Alzheimer; cancer; tumor suppressors; Pin1; Wnt signaling pathway
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Funding
- Fondecyt [1080569]
- National Institute on Aging [P50-AG05681, P01-AG03991]
- Charles and Joanne Knight Alzheimer Research Initiative of Washington University's Alzheimer Disease Research Center (CR)
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Cancer and Alzheimer's disease (AD) are two common disorders for which the final pathophysiological mechanism is not yet clearly defined. In a prospective longitudinal study we have previously shown an inverse association between AD and cancer, such that the rate of developing cancer in general with time was significantly slower in participants with AD, while participants with a history of cancer had a slower rate of developing AD. In cancer, cell regulation mechanisms are disrupted with augmentation of cell survival and/or proliferation, whereas conversely, AD is associated with increased neuronal death, either caused by, or concomitant with, beta amyloid (A beta) and tau deposition. The possibility that perturbations of mechanisms involved in cell survival/death regulation could be involved in both disorders is discussed. Genetic polymorphisms, DNA methylation or other mechanisms that induce changes in activity of molecules with key roles in determining the decision to repair and live -or die could be involved in the pathogenesis of the two disorders. As examples, the role of p53, Pin1 and the Wnt signaling pathway are discussed as potential candidates that, speculatively, may explain inverse associations between AD and cancer.
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