Journal
CURRENT ALZHEIMER RESEARCH
Volume 6, Issue 3, Pages 302-311Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156720509788486581
Keywords
Alzheimer's disease; retinoid; retinoic acid receptors; inflammation; immunology; regulatory T cell; neurodegeneration
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Alzheimer's disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.
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