Journal
CURRENT ALLERGY AND ASTHMA REPORTS
Volume 11, Issue 5, Pages 369-377Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-011-0212-9
Keywords
Primary immunodeficiencies; Innate immunity; Neutrophils; Macrophages; Dendritic cells; Natural killer cells; NK cells; NKT cells; Opsonins; Complement; Pattern-recognition receptors
Categories
Funding
- Intramural NIH HHS [Z99 AI999999] Funding Source: Medline
- NIAID NIH HHS [Y99 AI999999] Funding Source: Medline
Ask authors/readers for more resources
Primary immunodeficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. Innate immunity includes neutrophils, macrophages, dendritic cells, natural killer cells, and natural killer T cells in conjunction with natural barriers (mostly skin and gastrointestinal and respiratory mucosa), as well as antimicrobial agents, opsonins (e.g., complement), and cytokines. Although somewhat primitive, innate immune cells can orchestrate discrete immune responses through the recognition of diverse pathogens by different pattern-recognition receptors. In this review, we discuss the most recent discoveries as well as the already established pathophysiologic mechanisms underlying innate immunity defects associated with primary immunodeficiencies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available