Journal
CURRENT ALLERGY AND ASTHMA REPORTS
Volume 10, Issue 2, Pages 77-83Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-010-0088-0
Keywords
Occupational medicine; Rhinitis; Sinusitis; Inhalation injury; Atopy; Allergy; Pharyngitis; Laryngitis; Reflux disease
Categories
Funding
- Centers for Disease Control and Prevention and the National Institute for Occupational Safety and Health (CDC/NIOSH) [U10 OH008225]
- American Red Cross
- September 11 Fund
- Robin Hood Foundation
- Bear Stearns Charitable Foundation
- NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH [U10OH008225] Funding Source: NIH RePORTER
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The World Trade Center disaster and its recovery work involved a range of hazardous occupational exposures that have not been fully characterized but that can be reasonably assumed to have the potential to cause mucosal inflammation, preferentially (but not exclusively) in the upper airway. A high prevalence of rhinosinusitis and upper airway disease (UAD) symptoms was reported by several early surveys. Clinical studies demonstrated objective, clinically significant, and persistent chronic perennial rhinosinusitis and UAD-with or without seasonal exacerbation-in a large proportion of patients. Demonstration of an association between UAD and available exposure indicators has been limited. Atopy seemed to be associated with increased UAD symptom severity and to be a risk factor for upper, but not lower, airway disease. World Trade Center-related UAD is considered an irritant-induced disease but not, in many cases, of acute onset. No data thus far suggest an increased upper airway cancer incidence.
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