Journal
CRYSTENGCOMM
Volume 16, Issue 26, Pages 5887-5896Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ce00409d
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Funding
- FNRS
- University of Bologna
- Spinner PhD project
- MIUR
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Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl2 and CaCl2, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM).
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