Aliphatic Dicarboxylate Directed Assembly of Silver(I) 1,3,5-Triaza-7-phosphaadamantane Coordination Networks: Topological Versatility and Antimicrobial Activity

The present work describes the facile synthesis, full characterization, and architectural diversity of three new bioactive silver-organic networks, namely 1D [Ag-2(mu-PTA)(2)(mu-suc)]n.2nH(2)O (1), 2D [Ag-2(mu-PTA)(2)(mu(4)-adip)]n.2nH(2)O (2), and 3D [Ag-2(mu(4)-PTA)(mu(4)-mal)]n (3) coordination polymers, generated via a mixed-ligand strategy using PTA (1,3,5-triaza-7-phosphaadamantane) as a main building block and flexible aliphatic dicarboxylic acids (succinic (H2suc), adipic (H2adip), or malonic (H(2)mal) acids) as an ancillary ligand source. The compounds 13 were isolated as moderately air and light stable crystalline solids and were fully characterized by IR and H-1 and P-31{H-1} NMR spectroscopy, elemental analysis, ESI(+/-)-MS spectrometry, and single-crystal X-ray crystallography. The type of aliphatic dicarboxylate plays a key role in defining the dimensionality and structural and topological features of the resulting networks, which are also driven by the PTA blocks that adopt unconventional N,P- or N-3,P-coordination modes. The topological analysis of simplified underlying nets revealed that 1 possesses uninodal 3-connected chains with the SP 1-periodic net (4,4)(0,2) topology, 2 features a uninodal 4-connected layer with the skl topology, and 3 reveals a uninodal 4-connected metalorganic framework with the dia topology. The presence of the crystallization water molecules in polymers 1 and 2 gives rise to the extension of their metalorganic structures into 3D (1) or 2D (2) H-bonded networks that disclose rather rare topologies. All of the obtained silver(I) coordination polymers feature solubility in water (S-25 degrees C approximate to 35 mg mL(-1)) and show significant antibacterial and antifungal activity against the selected strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria and yeast (Candida albicans).