Polymorphic Co-crystals from Polymorphic Co-crystal Formers: Competition between Carboxylic Acid...Pyridine and Phenol...Pyridine Hydrogen Bonds

The recent literature has shown an increase in the number of co-crystals reported to be polymorphic, with at least 45 such systems identified thus far. The question of whether co-crystals, defined as any multicomponent neutral molecular complex that forms a crystalline solid, are inherently less prone to polymorphism than the individual components is shown to be untrue in four sets of polymorphic co-crystals. The co-crystal formers in this study, acridine, nicotinamide, 3-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, malonic acid, and pimelic acid, are all polymorphic in their unimolecular states and are shown to be dimorphic in the following combinations: (3-hydroxybenzoic acid).(acridine) [1(I) and 1(II)), (2,4-dihydroxybenzoic acid). (nicotinamide) [4(I) and 4(II)], (malonic acid).(nicotinamide) [5(I) and 5(II)], and (pimelic acid).(nicotinamide) [6(I) and 6(II)]. These co-crystals are assembled primarily using carboxylic acid and phenol hydrogen bond donors that hydrogen bond to pyridine N or amide carbonyl acceptors. Two different combinations of donors and acceptors are primarily responsible for the formation of polymorphs in 1 and 4, whereas conformational differences within the malonic and pimelic acid molecules lead to different packing arrangements using the same combination of hydrogen bonded interactions in 5 and 6. The 1:2 co-crystal of (3-hydroxybenzoic acid)center dot(acridine)2 (2) displays both the phenol O-H center dot center dot center dot N hydrogen bond observed in 1 (I) and the carboxylic acid O-H center dot center dot center dot N hydrogen bond observed in 1(11). In addition, a methanol solvate of (2,4-dihydroxybenzoic acid)center dot(nicotinamide) (3) is reported. DFT calculations show that the carboxylic acid center dot center dot center dot pyridine hydrogen bond is strongest and one of co-crystallization's most useful interactions.