Journal
CRYSTAL GROWTH & DESIGN
Volume 13, Issue 11, Pages 4877-4884Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cg401061t
Keywords
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Funding
- Finnish Cultural Foundation
- Academy of Finland [132726]
- Academy of Finland (AKA) [132726, 132726] Funding Source: Academy of Finland (AKA)
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The cocrystal formation potential of itraconazole, a potent antifungal drug, with C2-C10 aliphatic dicarboxylic acids has been investigated. Using two experimental screening techniques (solvent-assisted grinding and evaporation-based crystallization), the cocrystals of itraconazole with C2-C7 dicarboxylic acids have been successfully synthesized and characterized by powder X-ray diffraction, solid state nuclear magnetic resonance, Raman spectroscopy, and thermal analysis. The characterized multicomponent compounds include anhydrous cocrystals (malonic, succinic, glutaric, and pimelic acids), a cocrystal hydrate (adipic acid), and cocrystal solvates with acetone and tetrahydrofuran (oxalic acid). This study is the first to demonstrate the diversity in itraconazole cocrystals with a range of aliphatic dicarboxylic acids of variable carbon chain lengths.
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