Journal
CRYSTAL GROWTH & DESIGN
Volume 13, Issue 8, Pages 3290-3293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cg400686e
Keywords
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Funding
- U.S. Department of Energy Nuclear Energy University Programs Graduate Research Fellowship [DE-NE0000366]
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Anhydrous procainium acetate is a room temperature ionic liquid (T-g = -25 degrees C); however, in the presence of water, this salt forms a crystalline dihydrate (T-m = 52 degrees C) that cannot be dehydrated without decomposition. Unintended crystallization of any active pharmaceutical ingredient can dramatically alter its solubility and bioavailability, making it essential that ionic liquid APIs be carefully studied for their crystallization behavior.
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