Journal
CRYSTAL GROWTH & DESIGN
Volume 12, Issue 12, Pages 6260-6266Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cg301538y
Keywords
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Funding
- Merck
- Alcatel-Lucent Fellowship
- National Science Foundation [CHE-0714189]
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We describe a continuous microfluidic system for seeded crystallization of small organic molecules, such as active pharmaceuticals, and demonstrate integration with in situ detection tools for determining the size and polymorphic form of the crystals. This integrated device is used to extract growth kinetics, as a screening platform for process parameter effects and optimization, and to gain insight into the fundamentals of the crystallization process. In addition, the microfluidic system also allows studies of additive effects on the crystal habit. The method is demonstrated with growth kinetics for alpha-, beta-, and gamma-forms of glycine along with the effects upon the morphology of adding glutamic acid and methionine.
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