Journal
CRYSTAL GROWTH & DESIGN
Volume 11, Issue 12, Pages 5206-5214Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cg101708y
Keywords
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Funding
- Science Research Foundation of the Ministry of Health & United Fujian Provincial Health and Education [WKJ2008-2-54]
- Science and Technology Planning Project of Xiamen [3502Z20083013]
- Scientific and Technological Innovation Flat of Fujian Province [2009J1009]
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Reconstructed layers containing ordered enamel-like structures of fluoride-substituted hydroxyapatite (FHAp) microcrystals were constructed on a human enamel surface using ethylenediaminetetraacetic acid disodium salt dihydrate (EDTA) as the mediating agent under near-physiological conditions (pH 6.00, 37 degrees C, 1 atm). The effects of initial pH value, fluoride concentration, as well as reaction time on the formation of the FHAp microcrystals, including their micro-architectural structure, crystalline phase, chemical components, and hardness properties, were investigated using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Vickers microhardness measurements. The results of these in vitro experiments indicated that EDTA induced the assembly of hexagonal prismlike FHAp microcrystals along their c-axis direction, and the microcrystals further amalgamated with the extended reaction time. In addition, fluoride ions were found to play a critical role in the formation of hexagonal FHAp microcrystals. Interestingly, after reaction for 5 days, the Vickers microhardness of the new layer (347-370 VHN) was harder than that of natural tooth. On the basis of the experimental evidence, a mesoscale self-assembly mechanism was proposed to explain the growth of FHAp microcrystals.
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