Journal
CRYSTAL GROWTH & DESIGN
Volume 10, Issue 3, Pages 1028-1032Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cg901232h
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Funding
- American Foundation for Pharmaceutical Education
- University of Michigan College of Pharmacy
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Cocrystal eutectic constants (K-eu), the ratio of solution concentrations of cocrystal components at the eutectic point, are a fundamental indicator of phase behavior and are shown to be a function of the solubility ratio of cocrystal and drug in pure solvent. K-eu is shown to depend on solution chemistry including (i) solvent, (ii) complexation, and (iii) ionization, as does the solubility of cocrystals. More than 40 eutectic constants are presented and shown to provide essential information for cocrystal synthesis, selection, and formulation.
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