Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 3, Pages 349-354Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np500683u
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Funding
- BK21 Plus Program
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT and Future Planning) [2010-0020429]
- National Research Foundation of Korea [2010-0020429] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Fumiquinazoline S (1), a new quinazoline-containing alkaloid, and the known fumiquinazolines F (6) and L (7) of the same structural class were isolated from the solid-substrate culture of an Aspergillus sp. fungus collected from marine-submerged wood. In addition, isochaetominines A-C (2-4) and 14-epi-isochaetominine C (5), new alkaloids possessing an unusual amino acid-based tetracyclic core framework related to the fumiquinazolines, were isolated from the same fungal strain. The structures of these compounds were determined by combined spectroscopic methods, and the absolute configurations were assigned by NOESY, ROESY, and advanced Marfeys analyses along with biogenetic considerations. The new compounds exhibited weak inhibition against Na+/K+-ATPase.
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