Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 11, Pages 2699-2703Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00655
Keywords
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Funding
- National Natural Science Foundation of China [41176120, 21542001, 21372208]
- Shandong Provincial Natural Science Fund for Distinguished Young Scholars [JQ201422]
- NSFC-Shandong Joint Fund [U1406402]
- National High Technology Research and Development Program of China [2013AA092901]
- Program for New Century Excellent Talents in University [NCET-12-0499]
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Five new ambuic acid analogues, penicyclones AE (15), were isolated from the extract of the deep-sea-derived fungus Penicillium sp. F23-2. The structures including the absolute configurations were established by interpretation of NMR and MS data, as well as the application of ECD, X-ray crystallography, and a chemical conversion, as well as the TDDFT-ECD calculations. Penicyclones AE (15) exhibited antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus with MIC values ranging from 0.3 to 1.0 mu g/mL.
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