Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 9, Pages 2301-2305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00450
Keywords
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Funding
- National Natural Science Foundation of China (NSFC) [31270104]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
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Citrifelins A (1) and B (2), two citrinin adducts possessing a unique tetracyclic framework, were characterized from a coculture of marine-derived fungal isolates of Penicillium citrinum and Beauveria felina. Neither fungus produced these compounds when cultured alone under the same conditions. The structures of these adducts were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assigned on the basis of TDDFT-ECD calculations. A hypothesis that adducts 1 and 2 might be derived from a citrinin derivative through a non-pericyclic Michael reaction is proposed. Compounds 1, 2, and 5 showed inhibitory activities against several human and aquatic pathogens.
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