Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 12, Pages 3005-3010Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00749
Keywords
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Funding
- HHMI Professorship
- NSF [OISE 853408]
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
- Federal funds from the National Cancer Institute, National Institutes of Health [HHSN261200800001E]
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Endophytic fungi are plant tissue-associated fungi that represent a rich resource of unexplored biological and chemical diversity. As part of an ongoing effort to characterize Amazon rainforest-derived endophytes, numerous fungi were isolated and cultured from plants collected in the Yasuni National Park in Ecuador. Of these samples, phylogenetic and morphological data revealed a previously undescribed fungus in the order Pleosporales that was cultured from the tropical tree Duroia hirsuta. Extracts from this fungal isolate displayed activity against Staphylococcus aureus and were thus subjected to detailed chemical studies. Two compounds with modest antibacterial activity were isolated, and their structures were elucidated using a combination of NMR spectroscopic analysis, LC-MS studies, and chemical degradation. These efforts led to the identification of stelliosphaerols A (1) and B (2), new sesquiterpene-polyol conjugates that are responsible, at least in part, for the S. aureus inhibitory activity of the fungal extract.
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