Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 1, Pages 149-155Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00814
Keywords
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Funding
- NSFC-Joint Foundation of Yunnan Province [U1302223]
- National Natural Science Foundation of China [21322204, 21402213, 81172939]
- reservation-talent project of Yunnan Province [2011CI043]
- Youth Innovation Promotion Association
- West Light Foundation of the Chinese Academy of Science
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Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-beta (TGF-beta)/Smad signaling.
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