Journal
CRYOBIOLOGY
Volume 59, Issue 3, Pages 229-243Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cryobiol.2009.10.001
Keywords
Cryosurgery; Cryoablation; Cryotherapy
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Funding
- NCI NIH HHS [R43 CA128357-01A2, R43 CA128357, 1R43CA128357-01A2, R43 CA123993, R43 CA123993-01A1, R43 CA118537-02, 1R43CA123993-01A1, R43 CA118537, 1R43CA118537-02] Funding Source: Medline
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Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described. (C) 2009 Elsevier Inc. All rights reserved.
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