Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 8, Pages 2123-2127Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00031
Keywords
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Funding
- National Basic Research Program of China [2010CB833800]
- National Natural Science Foundation of China [81373304, U1405223]
- Fundamental Research Funds of Shandong University [2014JC027]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13028]
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Seven new benzoxazole derivatives, nocarbenzoxazoles A-G (1-7), were isolated from the halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on the basis of ID and 2D NMR spectroscopic data, HRESIMS, and X-ray single-crystal diffraction. The isolated compounds were assayed for their cytotoxicity against a panel of human tumor cell lines (HepG2, MDA-MB-23I, MDA-MB-435, HeLa, and PC3). Compounds 1-6 were found to have modest or no activity. Compound 7 showed selective activity against HepG2 and HeLa with IC50 values of 3 and 1 mu M, respectively.
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