Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 1, Pages 38-50Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00611
Keywords
-
Funding
- National Natural Science Foundation of China [81001373]
- Tianjin Applied Basic and Cutting-edge Technology Research Program [14JCYBJC29000]
Ask authors/readers for more resources
Investigation of the seeds of Thevetia peruviana resulted in the isolation of 15 new (2-16) and 18 known (1 and 17-33) cardiac glycosides. Eight 19-nor-cardenolides (1-8), including two rare 19-nor-10-hydroperoxycardenolides, were obtained from T. peruviana for the first time. All the structures were characterized by NMR spectroscopy and chemical derivatization. The inhibitory effects of cardiac glycosides 1-33 against three cancer cell lines (human lung cancer cells, P15; human gastric cancer cells, MGC-803; and human pancreatic cancer cells, SW1990) and one normal hepatocyte cell line, LO2, were evaluated, and a preliminary structure-activity relationship is discussed. In addition, cardiac glycosides 1, 22, 26, and 28 were evaluated for their apoptosis-inducing activities in MGC-803 cells, showing IC50 values in the range 0.02-0.53 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available