Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 3, Pages 363-367Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np5007586
Keywords
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Funding
- Marine Biotechnology Program, the Ministry of Oceans and Fisheries, Korea
- National Research Foundation of Korea, the Ministry of Science, ICT, and Future Planning, Korea [NRF-2012M1A5A1054307]
- BK21 program, the Ministry of Education, Korea
- National Research Foundation of Korea [2012M1A5A1054307] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 mu M, respectively.
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