Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 4, Pages 836-843Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00002
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Funding
- National Research Foundation of Korea (NRF) grant - Korean government (Ministry of ICT and Future Planning) [2014R1A2A1A11053477]
- Marine Biotechnology Program (Genome Analysis of Marine Organisms and Development of Functional Applications) - Ministry of Oceans and Fisheries, Korea [PJT200620]
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Salternamides A-D (1-4), the first secondary metabolites discovered from saltern-derived actinomycetes, were isolated from a halophilic Streptomyces strain isolated from a saltern on Shinui Island in the Republic of Korea. The planar structures of the salternamides, which are new members of the manumycin family, were elucidated by a combination of spectroscopic analyses. The absolute configurations of the salternamides were determined by chemical and spectroscopic methods, including the modified Moshers method, J-based configuration analysis, and circular dichroism spectroscopy. Salternamide A (1), which is the first chlorinated compound in the manumycin family, exhibited potent cytotoxicity against a human colon cancer cell line (HCT116) and a gastric cancer cell line (SNU638) with submicromolar IC50 values. Salternamides A and D were also determined to be weak Na+/K+ ATPase inhibitors.
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