Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 2, Pages 173-180Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np4009249
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico (FUNCAP)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Universidade Estadual do Ceara (UECE)
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The biological and pharmacological activities of the terpenoid terpinen-4-ol (1), which include depressant effects in the central nervous system, are of potential therapeutic interest. In the present study, the effects of 1 on neuronal excitability and voltage-dependent K+ currents in the somatic sensory system were investigated. Intact and dissociated neurons of rat dorsal root ganglia (DRG) were used for intracellular and patch-clamp recordings, respectively. In neurons of intact DRG, 1 caused concentration-dependent depolarization of the resting membrane potential and increased input resistance. 1 also inhibited action potentials (AP) and decreased AP parameters, with the exception of AP duration, which was increased. In dissociated DRG neurons, 1 partially blocked the total K+ current in a concentration-dependent manner. 1 inhibited I-A, I-D, and I-K with IC50 values of 3.2 +/- 03, 0.7 +/- 0.1, and 1.6 +/- 0.7 mM, respectively. 1 did not shift either the steady-state activation or inactivation curves of I-A, I-D, and I-K but reduced the decay time course of I-A. The alterations in DRG reported here are consistent with the inhibition of K+ currents and might partially explain the effect of 1 on excitable tissues.
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