Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 1, Pages 126-131Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00789
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Funding
- Medical Research Center Program (MRC) through the National Research Foundation of Korea [2008-0062275]
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Bioactivity-guided isolation of a methanolic extract of Euphorbia fischeriana led to the isolation of four new abietane-type diterpenoids, fischeriolides A-D (1-4), together with 11 known diterpenoids. Their structures were elucidated based on the interpretation of 1D and 2D NMR spectroscopic and HRESIMS data. The absolute configuration of compound 3 was determined by single-crystal X-ray diffraction analysis and electronic circular dichroism methods. Compounds 5-9 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 values in the range 4.9-12.6 mu M.
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