Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 3, Pages 607-610Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00770
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Funding
- University of Auckland
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The first occurrence of an acetylenic 1-amino-2-alcohol, distaminolyne A (1), isolated from the New Zealand ascidian Pseudodistoma opacum, is reported. The isolation and structure elucidation of 1 and assignment of absolute configuration using the exciton coupled circular dichroism technique are described. In addition, a new N-9 hydroxy analogue (2) of the known P. opacum metabolite 7-bromohomotrypargine is also reported. Antimicrobial screening identified modest activity of 1 toward Escherichia coli, Staphylococcus aureus, and Mycobacterim tuberculosis, while 2 exhibited a moderate antimalarial activity (IC50 3.82 mu M) toward a chloroquine-resistant strain (FcB1) of Plasmodium falciparum.
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