Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 12, Pages 3080-3082Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00853
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Funding
- Royal Society of New Zealand
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Herein is reported a synthesis of alocasin A (1), an alkaloid component of Alocasia macrorrhiza, a herbaceous plant used in folk medicine throughout southern Asia. A double Suzuki-Miyaura cross-coupling reaction between a 3-borylindole and 2,5-dibromopyrazine was used to assemble the heteroaromatic framework of the natural product. Removal of the protecting groups gave a synthetic sample of 1, the spectroscopic data of which matched those in the isolation report of this compound.
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