Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 11, Pages 2832-2836Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00594
Keywords
-
Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [2009-0083538]
Ask authors/readers for more resources
Paeciloketals (1-3), new benzannulated spiroketal derivatives, were isolated from the marine fungus Paecilomyces variotii derived from the giant jellyfish Nemopilema nomurai. Compound 1 was present as a racemate and was resolved into enantiopure 1a and 1b by chiral-phase separation on a cellulose column. Compounds 2 and 3, possessing a novel benzannulated spiroketal skeleton, were rapidly interconvertible and yielded an equilibrium mixture on standing at room temperature. The relative and absolute configurations of compounds 2 and 3 were determined by NOESY analysis and ECD calculations. Compound 1 showed modest antibacterial activity against the marine pathogen Vibrio ichthyoenteri.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available